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. 2006 Sep 1;6:219. doi: 10.1186/1471-2407-6-219

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Copyright © 2006 Powell et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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HOMUR cells that are resistant to DCA-induced apoptosis exhibit resistance to other anti-cancer agents. Parental HCT116 cells and HOMUR 7, 11, and 17 cells were plated at a density of 100,000 cells per 35 mm plate and incubated at 37°C for 48 hours. Subsequently etoposide (panel A) was added to a final concentration of 50 μM, cisplatin (panel B) added to a final concentration of 50 μM, or adriamycin (panel C) added to a final concentration of 1 μM to the plates. The cells were incubated with the drugs for 36 hours and then the number of apoptotic cells quantitated as described in Methods. The bars represent average values of three replicates. Error bars depict standard deviation. Astrisks denote a significant difference (p < 0.05) when compared with parental HCT116 cells.