TABLE 3.

Effect of PEMT promoter SNP rs12325817 (−744 G→C) on susceptibility to organ dysfunction in humans eating a low choline diet^a

	Signs of choline deficiency	GG	GC	CC	P value OR (95% CI)
All subjects (57)	Yes	7	25	7	0.10
	No	8	7	3
Men (26)	Yes	6	10	4	0.49
	No	1	2	3
All women (31)	Yes	1	15	3	0.002
	No	7	5	0	25 (2, 256)
Pre menopausal (16)	Yes	1	4	2	0.10
	No	5	4	0
Postmenopausal (15)	Yes	0	11	1	0.03
	No	2	1	0	42 (1, 1348)b

^aSubjects were fed a diet low in choline, and some developed signs of organ dysfunction (liver or muscle) that were reversed when choline was added back to their diets. Numbers of subjects are indicated for each genotype. Two-sided P values were calculated with a 2 × 3 Fisher exact test. For P < 0.05, odds ratios (OR) and 95% confidence intervals (CI) were calculated as the odds of showing signs of deficiency for subjects with the C allele divided by the odds of showing signs of deficiency for subjects without the C allele.

^bFor postmenopausal and premenopausal women (where some cells were 0; see above), the odds ratio and 95% confidence intervals were computed after adding 0.5 to each cell, so these values underestimate the true values.