TABLE 4.
Effect of choline dehydrogenase (CHDH) genotypes on susceptibility to organ dysfunction in humans eating a low choline dieta
|
CHDH rs9001, +318 A → C
|
CHDH rs12676, +432 G → T
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signs of choline deficiency | AA | AC | CC | P value OR (95% CI) | GG | GT | TT | P value OR (95% CI) | |
| All subjects (57) | Yes | 34 | 4 | 1 | 0.03 | 19 | 19 | 1 | 0.23 |
| No | 10 | 6 | 2 | 0.2 (0.05, 0.7) | 13 | 5 | 0 | ||
| Men (26) | Yes | 18 | 2 | 0 | 0.22 | 10 | 9 | 1 | 1.00 |
| No | 4 | 2 | 0 | 3 | 3 | 0 | |||
| All women (31) | Yes | 16 | 2 | 1 | 0.13 | 9 | 10 | 0 | 0.07 |
| No | 6 | 4 | 2 | 10 | 2 | 0 | |||
| Pre menopausal (16) | Yes | 6 | 1 | 0 | 0.39 | 2 | 5 | 0 | 0.04 |
| No | 4 | 3 | 2 | 8 | 1 | 0 | 20 (1, 282) | ||
| Postmenopausal (15) | Yes | 10 | 1 | 1 | 0.52 | 7 | 5 | 0 | 1.00 |
| No | 2 | 1 | 0 | 2 | 1 | 0 | |||
a
Subjects were fed a diet low in choline and some developed signs of organ dysfunction (liver or muscle), which reversed when choline was added back to their diets. Numbers of subjects are indicated for each genotype. Two-sided P values were calculated with a 2 × 3 Fisher exact test. For P < 0.05, odds ratios (OR) and 95% confidence intervals (CI) were calculated as the odds of showing signs of deficiency for subjects with the C allele (T allele for CHDH 432) divided by the odds of showing signs of deficiency for subjects without the C allele (T allele for CHDH 432).