TABLE 5.
PEMT rs7946 (+5465 G→A ) and BHMT rs3733890 (+742 G→A ) genotypes were not associated with changes in susceptibility to organ dysfunction in humans eating a low choline dieta
|
PEMT rs7946, +5465 G → A
|
BHMT rs3733890, +742 G → A
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signs of choline deficiency | GG | GA | AA | P value | GG | GA | AA | P value | |
| All subjects (54) | Yes | 5 | 16 | 15 | 0.86 | 21 | 11 | 4 | 0.84 |
| No | 3 | 9 | 6 | 9 | 7 | 2 | |||
| Men (26) | Yes | 4 | 8 | 8 | 1.00 | 12 | 6 | 2 | 1.00 |
| No | 1 | 3 | 2 | 4 | 1 | 1 | |||
| All women (28) | Yes | 1 | 8 | 7 | 0.75 | 9 | 5 | 2 | 0.65 |
| No | 2 | 6 | 4 | 5 | 6 | 1 | |||
| Pre menopausal (16) | Yes | 0 | 5 | 2 | 0.63 | 4 | 2 | 1 | 0.79 |
| No | 2 | 4 | 3 | 3 | 5 | 1 | |||
| Postmenopausal (12) | Yes | 1 | 3 | 5 | 0.66 | 5 | 3 | 1 | 1.00 |
| No | 0 | 2 | 1 | 2 | 1 | 0 | |||
a
Subjects were fed a diet low in choline and some developed signs of organ dysfunction (liver or muscle) that reversed when choline was added back to their diets. Numbers of subjects are indicated for each genotype. Two-sided P values were calculated with a 2 × 3 Fisher exact test. PEMT = phosphatidylethanolamine N-methyltransferase; BHMT = betaine:homocysteine methyltransferase.