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Proposed reaction mechanism for OMP decarboxylase. (A) Schematic representation of the reaction with the proposed transition state. (B) Stereoview of a model of the enzyme substrate complex. The OMP was generated by modeling a carboxylate group at C6 coplanar to the pyrimidine ring of UMP. The coordinates of UMP, Asp60, and Lys 62 were used without modification from the crystal structure.
