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. 2004 Mar 1;141(7):1193–1203. doi: 10.1038/sj.bjp.0705706

Figure 4.

Figure 4

Effect of AM251 on electrically evoked [3H]-DA release from human or rat neocortical slices. Following incubation with [3H]-DA, slices were superfused and stimulated electrically (S1–S3; 90 pulses, 40 mA, 3 Hz). (+)-Oxaprotiline and fluvoxamine (1 μM each) were present in the incubation and superfusion medium. AM251 was either given alone at increasing concentrations 70 min before S2 and S3 or, when tested in combination with 0.1 μM CP55.940, present from 70 min before S2 until the end of superfusion (in this case, CP55.940 was given 70 min before S3). Inset: Effect of 0.1 μM CP55.940 in the absence or presence of AM251 in the human neocortex (taken from data points presented in Figures 3, 4). Effects are given as mean normalized SX/S1 ratios±s.e.m., obtained from the neocortical tissue of four different patients or two different rats each resulting in 4–15 single data points. *P<0.05, **P<0.01, compared to the corresponding controls. •P<0.05, compared to the effect of 0.1 μM CP55.940 in the absence of 0.1 μM AM251.