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. 2004 Mar 15;141(7):1098–1105. doi: 10.1038/sj.bjp.0705718

Figure 4.

Figure 4

Concentration-dependent activation of Kir6.2/SUR2x channels by A-312110 and P1075. (a) Kir6.2/SUR2A, (b) Kir6.2/SUR2B channels. Data were obtained from experiments as shown in Figure 3. The KCO-induced current (IKCO) was normalised with respect to the peak current in the absence of MgATP before run-down, since run-down is reversed by MgATP (Ribalet et al., 2000). Concentration dependencies were analysed using the logarithmic form of the Hill equation with nH=1; n=3−12 per data point. Control currents in the presence of MgATP (1 mM) and absence of opener were 3.5 (0, 29)% of the current in the absence of ATP for Kir6.2/SUR2A (n=174) and 6.5 (0, 33) for Kir6.2/SUR2B (n=74; median and 95% confidence interval; P=0.027 by Mann–Whitney rank sum test).