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Derived parameters of (+)mefloquine [(+)MQ] and (−)mefloquine [(−)MQ] estimated for each of the two groups with or without elacridar
| Mefloquine alone | Pretreatment with elacridar | |||
|---|---|---|---|---|
| Parameters | (+)MQ | (−)MQ | (+)MQ | (−)MQ |
| CLcb (ml h−1) | 15.5 | 8.2 | 15.5 | 8.2 |
| CLbc (g h−1) | 8.2 | 2.9 | 3.3 | 1.9 |
| CLel (ml h−1) | 5.7 | 3.6 | 5.7 | 3.6 |
| Vc (ml) | 122 | 65 | 122 | 65 |
| Vb (g) | 77 | 34 | 19 | 13 |
| AUCc (μg ml−1 h) | 66 | 104 | 66 | 104 |
| AUCb (μg g−1 h) | 124 | 349 | 307 | 533 |
