Figure 4.

Time course of inflammatory cell influx and chemokine production in sponge implant in PAFR-KO and WT mice. Neutrophils (a) and macrophages (b) accumulation in the implants were measured as MPO and NAG activities, respectively. In the implants of PAFR-KO mice, the levels of these activities were markedly lower as compared with those of WT mice. Conversely, the levels of the chemokines, CXCL2(KC) and CCL2(MCP1/JE) were higher in the implants of PAFR-KO mice (c and d). Results are expressed as mean±s.e.m. of four to eight animals in each group. ^*P< 0.05; ^**P<0.01; ^***P<0.001.