Table 1.

Effects of the NK₃ receptor antagonist talnetant (SB-223412), on gastrointestinal motility in conscious rats. (a) The effects on gastric emptying were measured 45 min after administration of a liquid phenol-red test meal in conscious rats (Tache et al., 1987). (b) Effects on GI motility were measured 30 min after oral dosing of a charcoal meal to conscious rats (Takemori et al., 1969)

Groupa	Oral treatment	Dose (mg/kg)	% gastric emptying
1	Phenol red only	—	0.0
2	Vehicle	—	60.6
3	Talnetant	5	55.2
4	Talnetant	15	50.7
5	Talnetant	50	62.4
6	Morphine sulphate	20	30.8**
Groupb	Oral treatment	Dose (mg/kg)	Group mean distance travelled by charcoal as % of total gut length±s.d.	% change from vehicle-treated animals
1	Vehicle	—	53.0±7.6	−
2	Talnetant	5	46.9±5.3	−11.5
3	Talnetant	15	52.1±7.1	−1.7
4	Talnetant	50	50.4±8.6	−4.9
5	Morphine sulfate	10	37.4±12.4	−29.4

^aSignificance of difference from the vehicle-treated group: P<0.01 (ANOVA followed by William's test; talnetant groups, or Student's t-test; morphine).

^bStatistical significance of difference from the vehicle-treated group: ^**P<0.01 (as above). The doses of talnetant were selected to antagonise at the rat NK₃ receptor (Sarau et al., 1997) and were similar to those inhibit rat intestinal anti-nociceptive activity (Fioromonti et al., 2003). s.d.=standard deviation.