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. 2004 Apr 19;142(1):9–19. doi: 10.1038/sj.bjp.0705726

Figure 1.

Figure 1

DSI and endocannabinoids in the hippocampus. (a) Whole-cell recordings from a single hippocampal CA1 cell. sIPSPs (upper trace) in current clamp and sIPSCs (lower trace) in voltage clamp are inhibited by a brief train of action potentials. Notice the fast reversibility of the inhibition (from Pitler & Alger, 1992). (b) Endocannabinoids mediate the DSI of extracellularly eIPSCs in the hippocampus. On the right, the time course of DSI in CA1 pyramidal cells is shown for the control DMSO vehicle (open circles) and after applying the CB1R antagonist AM251 (dots). On the left, bars show the amount of DSI inhibition by two distinct CB1R antagonists, AM251 and SR141716, with sample traces for control DSI and DSI in antagonist depicted above (from Wilson & Nicoll, 2001).