Figure 5.

Effects of K_Ca channel blocker iberiotoxin on H₂O₂-induced membrane K⁺ currents (Imemb) in freshly isolated MA smooth muscle cells of SHR. (a) H₂O₂ markedly augmented K⁺ currents in control cells (dotted lines show the average before and during application of H₂O₂); (b) incubation with iberiotoxin abolished the effects of H₂O₂. Inserts in (a) and (b) show representative current sweeps obtained before and during the application of H₂O₂ from the sweeps indicated by asterisks; (c) percent increase of Imemb by H₂O₂ and the inhibitory effects of iberiotoxin (n=3–5 rats). ^**P<0.01 versus control.