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. 2004 Mar 22;142(1):172–180. doi: 10.1038/sj.bjp.0705738

Figure 4.

Figure 4

Recovery of 5-HT currents inhibited by S-citalopram and fluoxetine alone or with R-citalopram. Following a stable response to 10 μM 5-HT (application 1), the oocytes were pretreated for 5 min with R- or S-citalopram alone, or combinations thereof. Immediately thereafter, the R- and/or S-citalopram was coapplied with 10 μM 5-HT (application 2) until a steady current was obtained. Subsequently, 5-HT was reapplied three times allowing a 6 min washout period between each application (applications 3–5). The recovery response to 5-HT, relative to the initial response was calculated. (a) Effect of 0.45 μM R- and 0.15 μM S-citalopram alone plus their combination. (b) Effect of 5 μM R- and 0.15 μM S-citalopram plus their combination. (c) Effect of 5 μM R-citalopram and 1 μM fluoxetine plus their combination. Values are mean values±s.e.m. obtained from three to seven oocytes from at least two different batches of oocytes. *P<0.05, **P<0.01, ***P<0.001 (one-way analysis of variance followed by post hoc comparisons of means by t-test).