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. 2004 Mar 22;142(1):172–180. doi: 10.1038/sj.bjp.0705738

Figure 5.

Figure 5

Representative traces from oocytes expressing hSERT illustrating on- and off-set of R- and S-citalopram action in the presence of 10 μM 5-HT. (a) Upper panel: association of 1 μM S-citalopram in the presence of 5-HT; lower panel: association of 10 μM R-citalopram in the presence of 10 μM 5-HT. (b) Upper panel: dissociation of 1 μM S-citalopram in the presence of 10 μM 5-HT. Lower panel: dissociation of 10 μM R-citalopram in the presence of 10 μM 5-HT. (c) Fitted parameters, as described in the text, illustrating the differences in association and dissociation of R- and S-citalopram from hSERT in the presence of 10 μM 5-HT. The outward-going current observed when cells are treated with R- and S-citalopram alone can be ascribed to the inhibition of the leakage current mediated by the hSERT, as described in the introduction. However, its magnitude varies significantly between oocytes.