Table 1.

pEC₅₀ values of bradykinin, SNAP, L-SNC, D-SNC or DEA-NONOate in the absence or presence of several inhibitors

	pEC50
Inhibitor	Bradykinin	SNAP	L-SNC	D-SNC	DEA-NONOate
None	8.2±0.1 (45)	7.1±0.1 (14)	6.5±0.1 (22)#	6.0±0.1 (18)	6.6±0.1 (4)
Hoe140	<6 (3)*
Indomethacin	8.0±0.1 (5)
ODQ	7.2±0.2 (15)*	5.7±0.1 (11)*	5.3±0.1 (9)*	5.3±0.1 (13)*	5.8±0.1 (4)†
Hydroxocobalamin	6.8±0.2 (16)*	6.5±0.2 (11)*	5.4±0.2 (8)†	5.5±0.1 (13)*	5.9±0.1 (4)†
L-NAME	7.7±0.1 (23)†		7.5±0.3 (5)
Apamin	8.5±0.2 (7)		7.2±0.1 (4)
Charybdotoxin	8.2±0.2 (8)
Iberiotoxin	8.4±0.2 (6)		7.1±0.1 (4)
Charybdotoxin+apamin	7.6±0.3 (7)	7.2±0.1 (6)	6.0±0.1 (10)*	5.9±0.1 (13)	6.5±0.1 (4)
Iberiotoxin+apamin	8.8±0.2 (6)		7.1±0.2 (5)
Ouabain+BaCl2	8.7±0.1 (6)		6.7±0.1 (4)†
Glibenclamide			7.2±0.1 (5)
4-Aminopyridine			7.1±0.5 (4)
No endothelium			7.3±0.1 (9)†
No endothelium+charybdotoxin+apamin			7.0±0.1 (4)
ODQ+hydroxocobalamin		<5 (5)*‡	4.6±0.3 (5)*§	4.3±0.2 (12)*‡
ODQ+charybdotoxin+apamin		5.6±0.2 (5)*	5.3±0.1 (5)*	5.2±0.1 (5)*
Hydroxocobalamin+charybdotoxin+apamin		6.3±0.2 (6)†	5.3±0.2 (5)†	5.7±0.1 (5)†
ODQ+hydroxocobalamin+charybdotoxin+apamin		<5 (3)*‡	4.5±0.2 (5)*‡	4.3±0.2 (8)*‡

Data are mean±s.e.m. (n value);

^*P<0.01 vs none;

^†P<0.05 vs none;

^‡P<0.01 vs hydroxocobalamin or ODQ;

^§P<0.05 vs hydroxocobalamin or ODQ;

^#P<0.05 vs D-SNC.