Skip to main content
. 2004 Mar 29;142(1):43–50. doi: 10.1038/sj.bjp.0705756

Figure 1.

Figure 1

Effect of repeated exposure to U46619 on ACh-evoked hyperpolarization. Representative, original traces show: (a) a typical ACh-evoked smooth muscle hyperpolarization in the mesenteric artery; (b) the depressed response after three repeated exposures and washout of U46619 (30 nM–0.1 μM); (c) ACh cumulative concentration–response curves for smooth muscle hyperpolarization under control conditions, n=13, and after 3–4 repeated exposures and washout of U46619, n=8, are shown in the right segment (*P<0.05, Student's t -test). Resting membrane potential (rmp) for each group is shown in the left segment of the graph.