Figure 2.

MPO activity and NO_x and PGE₂ levels measured in paw homogenates from saline- and carrageenan-injected paws of CD1 8-week-old mice. Panel (a) shows the time dependence of MPO activity in 8-week-old CD1 mice that peaks at 6 h and remains elevated up to 24 h. The solid line represents basal MPO activity detected in saline-injected paws from the different groups studied (4.74±0.45 U MPO mg⁻¹ wet tissue). Panel (b) shows MPO values at 6 and 24 h in 3–8-week-old CD1 mice. Panels (c) and (d) show the time dependence of NO_x and PGE₂ production, respectively, in response to both saline (S) and carrageenan injection. For panels (a) and (b), values are mean±s.e.m. (n=6–10). ^**P< 0.01, in comparison to the 3-week-old mice; ⁺⁺P<0.01 in comparison to the basal levels (solid line). For panels (c) and (d), values are mean±s.e.m. (n=6–10). ^***P<0.001, ^**P< 0.01, ^*P<0.05 in comparison to the saline-injected group.