Figure 1.

Model for plasma, peripheral and brain compartments, where k₁₂ and k₂₁ are the transfer microconstants between the central and the peripheral compartments, k₁₀ is the elimination microconstant from the body, k_1b and k_b1 are the transfer microconstants between the central and the brain compartments, k_b0 is the elimination microconstant from the brain, k′_b0 is the sum of elimination and redistribution microconstants from the brain and D is the injected dose of norfloxacin. V₁, V₂ and V_b are the volumes of the compartments: central (V₁), peripheral (V₂) and cerebral (V_b), respectively.