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. 2004 May 20;142(2):323–330. doi: 10.1038/sj.bjp.0705748

Table 1.

PK parameter estimates obtained after an intravenous bolus administration of 150 mg kg of body weight−1 norfloxacin in rats by noncompartmental (NC) and compartmental (C) approachesa

Parameters (n=10) CLbplasma (ml min−1 kg−1) Vbss,plasma (ml kg−1) tc1/2,plasma (min) tc1/2,brain (min) Rds (%)
NC 13.0±2.2 4004±469 221±34 255±97 9.7±2.9
C 13.9±2.7 3622±492 202±45 8.9±2.8
a

PK parameter values are means±standard deviations.

b

Nonstatistically significant differences between mean values according to the approach used – compartmental (C) or noncompartmental (NC) – based on the paired Student's t test.

c

Nonstatistically significant differences between mean values of t1/2,brain and t1/2,plasma based on the paired Student's t-test.

d

Nonstatistically significant difference between the mean value of R calculated by AUC ratio and the mean value of Rmod estimated by the simultaneous modeling.