Table 1.

PK parameter estimates obtained after an intravenous bolus administration of 150 mg kg of body weight⁻¹ norfloxacin in rats by noncompartmental (NC) and compartmental (C) approaches^a

Parameters (n=10)	CLbplasma (ml min−1 kg−1)	Vbss,plasma (ml kg−1)	tc1/2,plasma (min)	tc1/2,brain (min)	Rds (%)
NC	13.0±2.2	4004±469	221±34	255±97	9.7±2.9
C	13.9±2.7	3622±492	202±45	−	8.9±2.8

^aPK parameter values are means±standard deviations.

^bNonstatistically significant differences between mean values according to the approach used – compartmental (C) or noncompartmental (NC) – based on the paired Student's t test.

^cNonstatistically significant differences between mean values of t_1/2,brain and t_1/2,plasma based on the paired Student's t-test.

^dNonstatistically significant difference between the mean value of R calculated by AUC ratio and the mean value of R_mod estimated by the simultaneous modeling.