Table 2.
PK–PD parameter estimatesa obtained after an intravenous bolus administration of 150 mg kg−1 norfloxacin in rats using the link model approach and the spline function model, with PK parameters obtained from plasma or brain ECF concentrations
| Parameters (n=10) | Ke0b (min−1) | P0 (mV2) | Bc (mV2 μM−1) | nb |
|---|---|---|---|---|
| PK–PD from plasma concentrations | 0.014±0.004 | 0.12±0.03 | 0.0122±0.0031 | 9±9 |
| PK–PD from brain ECF concentrations | 0.014±0.009 | 0.12±0.03 | 0.168±0.095 | 12±13 |
a
PK–PD parameter values are means±standard deviations.
b
Nonstatistically significant differences between mean values according to the PK data used, plasma or brain ECF concentrations based on the paired Student's t-test.
c
Statistically significant differences between mean values according to the PK data used, plasma or brain ECF concentrations based on the paired Student's t-test.