Table 2.
Parameters (n=10) | Ke0b (min−1) | P0 (mV2) | Bc (mV2 μM−1) | nb |
---|---|---|---|---|
PK–PD from plasma concentrations | 0.014±0.004 | 0.12±0.03 | 0.0122±0.0031 | 9±9 |
PK–PD from brain ECF concentrations | 0.014±0.009 | 0.12±0.03 | 0.168±0.095 | 12±13 |
PK–PD parameter values are means±standard deviations.
Nonstatistically significant differences between mean values according to the PK data used, plasma or brain ECF concentrations based on the paired Student's t-test.
Statistically significant differences between mean values according to the PK data used, plasma or brain ECF concentrations based on the paired Student's t-test.