Table 2.

Comparative pharmacology of canine and human BK receptors (FLIPR assay)

	HOE-140			[des-Arg10]HOE-140
	∼pIC50	∼pKi	Ref.	∼pIC50	∼pKi	Ref.
Canine PS cells	8.1	8.9	Figure 3	4.9	5.6	Figure 3
Canine PE cells	9.2	10.0	Figure 3	6.4	7.2	Figure 3
Canine B1 clone	ND	ND		7.0	7.7	*
Canine B2 clone	8.2	8.8	*	<6.0	ND	*
Human B1 clone	5.5	5.8	**	6.7	7.0	**
Human B2 clone	7.1	7.5	**	<5.5	ND	**
Human B2 clone	7.6	7.8	Figure 3	6.2	6.4	Figure 3

ND: not determined;

^*: Hess et al. (2001);

^**: Simpson et al. (2000).