Table 2.

Densities of specific B₂ receptor binding sites measured in the rat brain of 8- and 16-week-old WKY and SHR

	8 week-old		16 week-old
	WKY	SHR	WKY	SHR
Brain area					F1,12
Midbrain
Thalamus	2.95±0.29	2.06±0.25	1.48±0.39†	2.97±0.64*	7.92c
LDDM	4.01±0.46	3.03±0.11	2.29±0.74	2.99±0.56	2.61
LDVL	3.94±0.64	3.09±0.22	2.20±0.76	3.15±0.79	1.93
VPM	3.31±0.39	2.43±0.22	1.71±0.38†	3.05±0.75	5.45c
VPL	3.05±0.46	2.58±0.11	1.94±0.34	3.04±0.78	2.58
Hypothalamus	3.01±0.25	2.78±0.27	1.95±0.61	3.63±0.40 *	5.56c
DA	3.07±0.34	2.26±0.11	1.86±0.58	4.60±0.62***,††	14.72c
VMH	3.29±0.21	2.91±0.27	2.09±0.68	4.55±0.62**,†	8.45c
Amygdalaa,b	1.14±0.02	1.24±0.06	0.87±0.06	0.98±0.42	0.02
Hippocampus	1.01±0.03	1.65±0.12***	0.94±0.10	0.89±0.15†††	10.14c
Hindbrain
Colliculus	2.09±0.12	2.43±0.21	0.67±0.38	3.29±0.98**	4.48c
Subiculum	2.53±0.14	2.61±0.26	1.29±0.49	2.62±0.91	1.37
Pna,b	1.91±0.13	2.98±0.34	0.45±0.26	1.04±0.46	0.56
PDTga	5.23±0.97	11.30±1.08	5.95±1.07	10.78±0.85	0.39
CGAa	3.33±0.41	4.88±0.58	3.88±1.10	7.71±0.93	2.01
SCP	4.67±1.07	3.74±0.94	2.24±0.88	6.56±0.43**,†	9.26c
SP5a	5.72±0.42	12.94±0.53	5.69±0.36	10.68±1.11	2.71
PA5a,b	4.23±0.47	9.21±0.64	1.78±0.54	5.23±0.99	1.22
NTS	3.24±0.30	3.60±0.72	0.79±0.24†	4.17±1.14**	4.66c
Pyt	1.75±0.30	2.01±0.15	0.26±0.16†	2.14±0.39***	9.26c
Amb	2.09±0.39	1.72±0.91	0.22±0.19†	2.94±0.52**	7.45c

Data are means±s.e.m. of four rats. Values represent densities measured in fmol mg⁻¹ tissue.

^aSignificant difference between WKY and SHR but not dependent on age.

^bSignificant difference between 8 weeks and 16 weeks but not dependent on strains.

^a,bSignificant differences between both strains and ages.

^cF-values showing strain and age interaction. In that case, significant differences are between SHR and age-matched WKY (^*P< 0.05; ^**P< 0.01; ^***P< 0.001) or between 8 and 16 weeks in each strain (^†P<0.05; ^††P<0.01; ^†††P<0.001).