. 2004 Apr 5;142(2):285–296. doi: 10.1038/sj.bjp.0705759

Table 3.

Densities of specific B₁ receptor binding sites measured in the rat brain of 8 and 16 week-old WKY and SHR

	8 week-old		16 week-old
	WKY	SHR	WKY	SHR
Brain area					F_1,12
Cortical regions
Parietal cortex	0.41±0.21	0.52±0.19	0.07±0.02	1.35±0.33^**,†	7.29^c
Occipital	0.81±0.16	0.88±0.26	0.22±0.02^†	1.88±0.15^**,†††	21.25^c
Perihinal/entorhinal	0.33±0.19	0.64±0.22	0.16±0.01	1.57±0.22^***,††	8.89^c
Midbrain
Thalamus	0.37±0.16	0.44±0.17	0.08±0.02	0.87±0.17^**	5.98^c
LDDM	0.45±0.06	0.45±0.16	0.08±0.03	1.10±0.21^***,††	14.02^c
LDVL	0.46±0.10	0.43±0.23	0.09±0.02	1.04±0.25^**,†	7.69^c
VPM^a	0.44±0.19	0.56±0.21	0.08±0.02	0.76±0.17	2.89
VPL	0.44±0.19	0.41±0.07	0.14±0.07	0.82±0.17^**,†	7.41^c
Hypothalamus^a	0.39±0.15	0.54±0.18	0.10±0.01	0.80±0.20	3.33
DA^a	0.44±0.18	0.50±0.26	0.09±0.01	0.86±0.17	3.96
VMH^a	0.30±0.08	0.44±0.18	0.13±0.02	0.83±0.20	4.08
Amygdala	0.52±0.20	0.45±0.16	0.14±0.01	1.90±0.30^{***,†††}	21.41^c
Hippocampus	0.34±0.10	0.54±0.16	0.17±0.04	1.35±0.29^***,††	7.87^c
Hindbrain
Colliculus	0.72±0.13	0.66±0.13	0.12±0.03^††	0.65±0.15^**	5.93^c
Subiculum	0.73±0.07	0.76±0.12	0.15±0.01^†††	0.85±0.13^***	12.31^c
Pn	0.65±0.15	0.26±0.11^*	0.02±0.01^†††	0.07±0.07	5.07^c
PDTg^a,b	0.29±0.02	0.41±0.09	0.13±0.01^†††	0.26±0.08	0.02
CGA	0.13±0.09	0.30±0.06	0.12±0.02	0.10±0.03	3.12
SCP	0.14±0.10	0.38±0.12	0.10±0.02	0.18±0.06	0.85
SP5	0.17±0.11	0.39±0.16	0.18±0.03	0.22±0.12	0.57
PA5	0.28±0.15	0.25±0.15	0.16±0.03	0.13±0.06	0.00
NTS	0.20±0.13	0.42±0.20	0.17±0.04	0.19±0.12	0.53
Pyt	0.18±0.16	0.12±0.09	0.08±0.02	0.10±0.02	0.17
Amb	0.08±0.06	0.30±0.18	0.17±0.04	0.18±0.14	0.74

Data are means±s.e.m. of four rats. Values represent densities measured in fmol mg⁻¹ tissue.

Significant difference between WKY and SHR but not dependent on age.

Significant difference between 8 weeks and 16 weeks but not dependent on strains.

^a,b

Significant differences between both strains and ages.

F-values showing strain and age interaction. In that case, significant differences are between SHR and age-matched WKY (^*P< 0.05; ^**P< 0.01; ^***P< 0.001) or between 8 and 16 weeks in each strain (^†P<0.05; ^††P<0.01; ^†††P<0.001).