Figure 4.

Effects of glucose on nateglinide-induced insulin secretion in the presence of membrane-depolarizing conditions (30 mM KCl). Following 40 min preincubation with a buffer containing 1.1 mM glucose, effects of glucose (0–30.0 mM) in the absence or presence of 200 μM nateglinide were tested during a 20 min incubation period. Values are mean±s.e.m. (n=6). ^**P<0.01, ^***P<0.001 compared with the respective effect in the absence of glucose. ΔΔΔP<0.001 compared with the respective effect in the absence of 200 μM nateglinide.