Figure 1.

Effects of idazoxan (1 μM) on NA-induced oxidation currents. (a,b) Overlaid averaged traces of oxidation currents evoked by 10 stimuli at 1 (a) and 10 Hz (b) recorded before and during application of idazoxan. (c,d) Histograms showing the effects of idazoxan on the amplitude of the oxidation currents evoked by trains of 10 stimuli at 1 (c) and 10 Hz (d) (n=6). In (c), the amplitude of the oxidation current was measured following the first and last (10th) stimulus of the train of stimuli. Statistical comparisons were made between the T₂/T₁ ratios in drug-treated and untreated control tissues (n=6) (unpaired t-tests, ^*P<0.01). Idazoxan increased the amplitude of the NA-induced oxidation currents measured at end of the trains of stimuli.