Figure 3.

Effects of idazoxan (1 μM) on electrical responses to nerve stimulation recorded in deep cells. (a,b) Averaged traces of e.j.p.'s and slow depolarizations evoked by 10 stimuli at 1 (a) and 10 Hz (b) recorded before and during application of idazoxan. (c) Graph showing the change in amplitude of e.j.p.'s evoked by 10 stimuli at 1 Hz in control (n=6) and idazoxan-(n=6) treated tissues. (d) Histogram showing the effect of idazoxan on the peak amplitude and the amplitude measured immediately following the last stimulus (end) of the train of 10 stimuli at 10 Hz. Idazoxan had no effect on e.j.p. amplitude but abolished the neurally evoked slow depolarization.