Figure 6.
Effects of clonidine (0.5 μM) on electrical responses evoked by 10 stimuli at 1 Hz in deep cells. (a) Averaged traces of e.j.p.'s and slow depolarizations recorded before and during application of clonidine followed by idazoxan (1 μM). (b) Graph showing the effects of clonidine alone (T2/T1) and clonidine plus idazoxan (T3/T1) on the amplitudes of e.j.p.'s evoked by the trains of stimuli at 1 Hz (n=6). For clonidine, statistical comparisons were made between the T2/T1 ratios in control (see Figure 3c) and drug-treated tissues (unpaired t-tests, *P<0.01). For the effects of adding idazoxan, the mean T3/T1 ratio in the presence clonidine plus idazoxan was compared with the mean T2/T1 ratio in the presence of clonidine alone (paired t-tests, ‡P<0.01). Clonidine reduced the amplitude of e.j.p.'s and this effect was reversed by idazoxan.