Figure 7.

(a) A representative trace showing the 340 : 380 nm ratios in a single DRG neurone, in response to capsaicin in the presence of 1 μM noladin ether. The cell is initially exposed to capsaicin (100 nM) for 60 s; after a 45 min washout period, noladin ether was applied alone for 4 min; a combination of capsaicin and noladin ether was then applied for 60 s. After a further 45 min, the cell was challenged with capsaicin alone. (b) Effect of 1 μM noladin ether on capsaicin-induced calcium response in individual DRG cells (n=52), compared with the response to capsaicin alone in separate control experiments (n=35). Results are expressed as percentages of the responses to 100 nM capsaicin alone.