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. 2004 May 17;142(3):495–500. doi: 10.1038/sj.bjp.0705792

Figure 3.

Figure 3

Dose–response curves for endogenous, plant-derived and synthetic agonists. (a) Oocytes were perfused with AM1902, AM782, AM2233, AM411, and WIN55,212-2 at the indicated concentrations. Despite widely varying EC50's, all compounds showed full agonism. (b) Oocytes were perfused with anandamide, AM356, 2-AG (ester), 2-AG ether, Δ9-THC, and WIN55,212-2 at the indicated concentrations. 2-AG and WIN55,212-2 were fully efficacious at 10 μM, whereas, 2-AG ether, Δ9-THC, anandamide, and AM356 elicited only 40–60% of the Maximal WIN Response at 10 μM (N=11–20 per concentration).