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. 2004 May 17;142(3):576–584. doi: 10.1038/sj.bjp.0705796

Table 1.

Effects of lidocaine on fast activation, inactivation and slow inactivation parameters for Na_v 1.7 and Na_v 1.8

	Activation			Inactivation			Slow inactivation
	V_1/2 (mV)	k_v	n	V_1/2 (mV)	k_v	n	τ_F (ms)	τ_I (ms)	τ_S (ms)	n
Na_v 1.7, control	−25.56±1.53	−3.75±0.17	5	−68.38±0.42	4.37±0.08	5	14.42±2.95	428.88±92.83	989.50±165.88	4
Na_v 1.7, lidocaine (100 μM)	−23.92±1.85	−3.89±0.22	5	−79.02±1.49^*	5.52±0.24^*	5	2.40±0.40^*	47.00±3.62^*	107.60±59.88^*	4
Na_v 1.8, control	6.24±0.68	−5.73±0.21	5	−42.72±1.23	9.05±0.08	5	11.27±0.22	31.54±8.42	1656.34±278.81	5
Na_v 1.8, lidocaine (100 μM)	12.32±1.78^*	−6.63±0.26	5	−46.81±0.58^*	8.07±0.20^*	5	6.52±0.85^*	6.65±0.73^*	6.49±0.86^*	5

τ_F=fast inactivation time constant; τ_I=intermediate inactivation time constant; τ_S=slow inactivation time constant; n=number of experiments.

^*

=P<0.05.