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Effect of H. perforatum extract (60 mg kg−1 i.p.) given at time 0 min (arrow) on extracellular concentrations of DA, NA, 5-HT and metabolites DOPAC, HVA and 5-HIAA in the PFC of the awake rat. The data are expressed as percentage of control levels at 0 min; the values at individual time points were compared to the basal levels at −20 min; (★) P<0.05; (★★) P<0.01; (★★★) P<0.001, one-way ANOVA, Student–Newman–Keuls test, mean±s.e.m., n=5 rats.
