Table 1.

Effect of H. perforatum (300 mg kg⁻¹ p.o.) and phenelzine (5 mg kg⁻¹ i.p.) on tissue concentrations of DA, DOPAC, HVA, 5-HT and 5-HIAA, and on DA and 5-HT turnover in the PFC and striatum of the awake rat, 180 min after the drug administration

	DA	DOPAC	HVA	5-HT	5-HIAA	DA turnover	5-HT turnover
PFC
Vehicle	62±9	27±3	66±4	1641±78	1429±90	1.585±0.164	0.874±.051
Hypericum	36±22	24±5	81±9	1507±105	1521±75	6.614±1.586**	1.026±0.051
Phenelzine	58±4	11±2	52±4	2034±194	831±129	1.124±0.158	0.427±0.080***
Striatum
Vehicle	17838±2316	1634±214	1395±247	718±116	2247±306	0.168±0.007	3.177±0.104
Hypericum	16168±599	1817±93	1390±171	603±25	2455±128	0.199±0.015	4.098±0.246*
Phenelzine	19006±591	626±219	582±136	879±57	1625±154	0.066±0.022***	1.947±0.322**

The concentrations are expressed in ng g⁻¹ wet weight, DA and 5-HT turnover as the ratio of (DOPAC+HVA)/DA and 5-HIAA/5-HT, respectively, mean±s.e.m., n=6 rats;

^*P<0.05, ^**P<0.01, ^***P<0.001, ANOVA, Fisher's PLSD test.