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Vasodilatation induced by CORM-3. Isometric recordings of aortic rings precontracted with phenylephrine (Phe, 1 μM) and subsequently subjected to a bolus addition of CORM-3 (100 μM) or iCORM-3 (100 μM). Typically, CORM-3 was added to the water bath containing aortic rings once phenylephrine had produced a stable contraction; CORM-3 caused relaxation within few minutes of addition whereas iCORM-3 was ineffective.
