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. 2004 May 17;142(3):453–460. doi: 10.1038/sj.bjp.0705825

Figure 2.

Figure 2

Effect of CORM-3 on vascular tone: involvement of cGMP and KATP channels. (a) Vasodilatory responses of aortic rings subjected to three consecutive bolus additions of CORM-3 at different concentrations (25–100 μM). iCORM-3 (100 μM), the negative control, did not cause any evident relaxation. Vasodilatation is expressed as percentage of the maximal preconstriction. Data represent the mean±s.e.m. of 6–8 independent experiments. *P<0.05 compared to iCORM-3. (b) Vasodilatory responses of aortic rings subjected to three consecutive bolus additions of CORM-3 in the presence of ODQ (10 μM) or glibenclamide (Gli, 10 μM). ODQ and glibenclamide were added to the water bath 15 or 30 min prior to the addition of phenylephrine, respectively. Dilatations are expressed as percentage of preconstriction. Data represent the mean±s.e.m. of 6–8 independent experiments. *P<0.05 compared to 100 μM CORM-3 alone.