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cGMP levels in aortas treated with CORM-3. Aortas were extracted and subjected to the same treatments with CORM-3 as for measurements of isometric tension. At 8 min after the first, second or third addition of CORM-3 (100 μM), aortas were snap-frozen and subsequently processed for cGMP assay. Control aortas (CON) were treated with vehicle (water). Data represent the mean±s.e.m. of four different aortas per group. *P<0.05 compared to control.
