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. 2004 May 17;142(3):453–460. doi: 10.1038/sj.bjp.0705825

Figure 7.

Figure 7

Blockade of NO production or removal of the endothelium reduces CORM-3-mediated dilatory responses. (a) Aortic rings were incubated with the inhibitor of NO synthase activity L-NAME (100 μM) for 30 min prior to contraction with phenylephrine. L-NAME markedly prevented relaxation caused by 100 μM CORM-3, and higher concentrations of the CO carrier (200 or 400 μM) were required to induce dilatation in the presence of L-NAME. Data represent the mean±s.e.m. of 6–8 independent experiments. *P<0.05 compared to 100 μM CORM-3 alone. (b) The endothelium of aortic rings was gently removed (−E) as described in Methods and the response to CORM-3 was compared to that of intact rings (+E). The absence of the endothelium markedly reduced CORM-3-mediated vasodilatation and higher CORM-3 concentrations were required to produce relaxation. Data represent the mean±s.e.m. of 6–8 independent experiments. *P<0.05 compared to 100 μM CORM-3 alone.