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. 2004 May 24;142(4):756–764. doi: 10.1038/sj.bjp.0705819

Figure 3.

Figure 3

Effect of drug treatment 45 min prior to intestinal reperfusion. (a) I/R-induced intestinal oedema. Pretreatment with the C3aRA, at 0.3 or 1.0 mg kg−1 i.v. and C5aRA at 1.0 mg kg−1 i.v., significantly attenuated I/R-induced oedema in the rat intestine. Data are shown as mean±s.e.m. *P⩽0.05 when compared to I/R animals, + P⩽0.05 when compared to sham animals. (b) Effect of antagonists on elevation of serum ALT following I/R. Elevation of serum ALT following intestinal I/R is attenuated by treatment with a C3aRA (1.0 mg kg−1) or C5aRA (1.0 mg kg−1). Administration of both the C3aRA and C5aRA (both 1.0 mg kg−1 i.v.) to sham-operated animals resulted in an elevation in ALT that was not associated with I/R. Data are expressed as mean±s.e.m. * P⩽0.05 when compared to I/R animals. +P⩽0.05 when compared to sham-operated animals. S, sham.