Figure 3.
Traces from representative experiments showing the influence of LPS on the increase in basal DBP induced by ES (S1–S4: 1 Hz, 1 ms, 50 V for 10 s) of the preganglionic sympathetic nerve fibers in pithed and vagotomized rats. Experiments were performed in the presence of the cannabinoid CB1 receptor antagonist SR 141716A (SR; 0.1 μmol kg−1; b) or its solvent (Sol; a), injected (solid arrows) 10 min prior to the first period of ES S1 and in the presence of pancuronium (P; 0.8 μmol kg−1), injected (solid arrows) 5 min prior to S1. At 5 min after S1, a single dose of LPS was injected (solid arrows). An infusion of vasopressin (VP; hatched arrows) started 2 min earlier. Three subsequent periods of ES (S2, S3 and S4) were applied at 10 min intervals. For details concerning the experimental protocol, see Figure 1.