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. 2004 Jun 14;142(5):879–889. doi: 10.1038/sj.bjp.0705852

Table 2.

Effect of CTX on activation kinetics of INa as measured by time-to-peak INa

  n Control 1 3 10
rNav1.2 7 0.62±0.06 0.52±0.05*    
  3 0.61±0.08   0.53±0.10*  
  3 0.41±0.02     0.35±0.02*
rNav1.4 6 0.56±0.04 0.55±0.04    
  3 0.39±0.04   0.33±0.04**  
  3 0.49±0.07     0.41±0.07
rNav1.5 6 0.71±0.09 0.71±0.07    
  3 0.46±0.02   0.39±0.01*  
  3 0.51±0.05     0.45±0.03

Time-to-peak INa (ms) is given for the control (no CTX) and the indicated concentrations of CTX (μmol l−1). CTX accelerated time-to-peak INa most markedly in isoform rNav 1.2, that is, by 0.1 ms.

*

P<0.05 vs control,

**

P<0.01 vs control.