Figure 2.

Chelerythrine and its structural analogues, sanguinarine and berberine, block ATP-induced ⁸⁶Rb⁺ efflux. ⁸⁶Rb⁺-loaded CLL B-lymphocytes in KCl medium containing 20 μM CaCl₂ were pre-incubated for 5 min at 37°C in the presence of 10 μM sanguinarine, 10 μM berberine or 10 μM chelerythrine, or in the absence of inhibitors, before the addition of 100 μM ATP for a further 4 min. The data are one representative of 13 experiments for chelerythrine and three experiments for sanguinarine and berberine.