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Typical record showing vascular responses to nicotine (a) and the effect of capsazepine (b) in rat perfused mesenteric vascular beds without endothelium and with active tone produced by methoxamine (2 μM). SD, perfusion of SD for 30 s. ACh, bolus injection of ACh (1 nmol; closed circles). PNS, periarterial nerve stimulation (2 Hz; closed inverted triangles). Nicotine (1–100 μM) was perfused for 1 min at times indicated by the horizontal bars. PPV, perfusion of 100 μM papaverine.
