Table 1.
Effects of capsazepine and ruthenium red on vasodilator responses induced by periarterial nerve stimulation (PNS, 2 Hz), bolus injection of CGRP (100 pmol) and perfusion of capsaicin (30 nM) in rat mesenteric vascular beds without endothelium
| Vasodilation (%) induced by | |||
|---|---|---|---|
| PNS (2 Hz) (n) | CGRP (100 pmol) (n) | Capsaicin (30 nM) (n) | |
| Control | 80.7±4.3 (5) | 91.4±3.6 (4) | 90.4±1.1 (4) |
| Capsazepine | |||
| 1 μM | 81.2±3.2(5) | 96.1±0.7 (3) | 30.7±8.9** (3) |
| 5 μM | 63.0±5.2* (5) | 90.4±3.4 (3) | 6.9±3.6** (3) |
| 10 μM | 43.4±6.7** (6) | 85.3±2.4(5) | 2.5±0.5** (3) |
| Ruthenium red | |||
| 1 μM | 87.5±1.8(6) | 84.2±5.9(4) | 63.6±6.8** (4) |
| 10 μM | 54.1±9.2* (5) | 82.6±5.4 (5) | 0.5±4.1** (4) |
| 30 μM | 25.4±1.7** (6) | 79.2±4.8 (5) | 0.5±0.8** (4) |
(n): number of animals.
*
P<0.05,
**
P<0.01, compared with control.