Figure 5.

I_Kr and I_Ks inhibition by ranolazine. (a, b) I_Kr from a representative cell before (a) and after application of 100 μmol l⁻¹ ranolazine (b). Currents were elicited by the protocol shown in the inset. (c) Concentration–response curve of mean data at a test potential of 0 mV. ^*P<0.05, ^**P<0.01 vs control, n=10. (d, e) Representative I_Ks recordings before (d) and after 1 mmol l⁻¹ ranolazine (e). (f) Concentration–response curve of mean data at a test potential of +40 mV. ^*P<0.05, ^**P<0.01 vs control, n=6.