Figure 6.

I_Ca inhibition by ranolazine. (a, b) I_Ca current recordings before (a) and after application of 300 μmol l⁻¹ ranolazine (b). Currents were elicited from a holding potential of −50 mV to test potentials between −40 mV (arrow) and +60 mV as shown by the protocol in the inset. (c) Mean current–voltage relationships under control conditions (filled circles) and in the presence of 300 μmol l⁻¹ ranolazine (open circles). (d) Mean concentration–response curve at a test potential of 10 mV. Results are mean±s.e.m. ^*P<0.05 and ^**P<0.01 vs control, n=8.