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. 2004 Jul 19;142(8):1265–1272. doi: 10.1038/sj.bjp.0705892

Figure 1.

Figure 1

Effect of IBMX on mediator generation. The effects of IBMX on the generation of (a) IL-4 and histamine and (b) IL-13 and histamine from human basophils were determined. Cells were incubated for 15 min with IBMX before challenge with anti-IgE (1 : 100,000 or 1 : 10,000) for (a) 4 h or (b) 24 h. Values are expressed as the % inhibition of the control releases, which were for (a), 73±31 pg of IL-4 per 106 basophils and 42±6% histamine release and for (b), 8±2 pg of IL-13 per 106 basophils and 21±6% histamine release. Values are means±s.e.m., n=5 for both (a) and (b). Asterisks denote; *P<0.05, **P<0.01.