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Effects of cyclic nucleotides on histamine release from basophils. Cells were incubated without or with analogues of cAMP or cGMP for 30 min before challenge with anti-IgE (1 : 100,000 or 1 : 10,000) for a further 45 min. Values are expressed as the % inhibition of the control histamine release, which was 34±7%. Values are means±s.e.m., n=4. Asterisks denote; **P<0.01.
