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. 2004 Jul 26;142(8):1281–1292. doi: 10.1038/sj.bjp.0705895

Figure 7.

Figure 7

(a) Effect of increasing concentrations of amphotericin B (0.25–2.5 μg ml−1) applied from the apical cell border upon short-circuit current (ΔIsc, μA cm−2) in Caco-2 cells. (b) Effect of removal of Na+ from the solution bathing the apical cell side and ouabain (500 μM) upon changes in short-circuit current (ΔIsc, μA cm−2) induced by amphotericin B (1.0 μg ml−1) applied from the apical cell side. (c) Effect of cAMP (0.5 mM) and PDBu (1 μM) upon changes in short-circuit current (ΔIsc, μA cm2) induced by amphotericin B (1.0 and 2.5 μg ml−1) applied from the apical cell side. Columns represent the mean of three to nine experiments per group and vertical lines show s.e.m. Significantly different from values for 0.25 μg ml−1 amphotericin B (#P<0.05) or corresponding control values (*P<0.05) using the Newman–Keuls test.