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NCX-1000 inhibits APAP-induced expression of TNF-α, IFN-γ, Fas and FasL mRNA in the liver. Each panel is representative of at least three other PCRs carried out, each one using a different liver. Symbols are ‘M' base pairs. ‘+' positive control. ‘−' negative control. Lane 1: control. Lane 2: APAP 330 μmol kg−1 i.p. Lane 3, APAP plus UDCA 40 μmol kg−1 i.p. 2 h after APAP; and lane 4, APAP plus NCX-1000 40 μmol kg−1 i.p. 2 h after APAP.
