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. 2004 Sep 2;143(1):33–42. doi: 10.1038/sj.bjp.0705780

Figure 5.

Figure 5

NCX-1000 releases NO and rescues mouse hepatocytes from death caused by APAP. Panel (a) Time course of NO concentrations in primary cultures of mouse hepatocytes incubated with increasing concentrations of APAP, UDCA and NCX-1000 for 6 h. Data are means±s.e. of six experiments. *P<0.01 versus control. Panel (b) Effect of NCX-1000 and UDCA (50 μM) on apoptosis induced by APAP (6.6 mM). The percentage of apoptotic cells (annexin V+/PI−) is shown. Data are mean±s.e. of six experiments. *P<0.05 versus control; **P<0.05 versus APAP alone. Panel (c) Effect of NCX-1000 and UDCA (50 μM) on hepatocytes necrosis (annexin V+/PI+) induced by APAP (6.6 mM). Data are mean±s.e. of six experiments. *P<0.05 versus control; **P<0.05 versus APAP alone. Panel (d) Effect of increasing concentrations of NCX-1000 on hepatocyte apoptosis caused by exposure to 6.6 mM APAP for 24 h. The percentage of apoptotic cells (annexin V+/PI−) is shown. Data are mean±s.e. of six experiments. *P<0.05 versus APAP alone.