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. 2004 Sep 2;143(1):33–42. doi: 10.1038/sj.bjp.0705780

Figure 8.

Figure 8

Panel (a) Treatment with DETA-NO, 50 μM, prevents cleavage of procaspase-3 and -9 and PARP and attenuates cytochrome c translocation induced by APAP. Hepatocytes were incubated for 6 h as described in Methods. Lane 1: control cells. Lane 2: APAP, 6.6 mM, alone. Lane 3, APAP plus 50 μM DETA-NO. Each blot is representative of at least three other experiments Panel (b) DETA-NO protects from APAP-induced apoptosis. Data are mean±s.e. of six experiments. *P<0.05 versus control; **P<0.05 versus APAP alone.